Taxel therapies less effective in the TP53+ biomarker signature
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| — | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.049, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 18.7, median = 15.3 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.48, hr = 2.6 | af = 1, hr = 1 | |
| -++ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.049, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 18.7, median = 15.3 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.48, hr = 2.6 | af = 1, hr = 1 | |
| +– | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.049, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 18.7, median = 15.3 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.48, hr = 2.6 | af = 1, hr = 1 | |
| +++ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.049, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 18.7, median = 15.3 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.48, hr = 2.6 | af = 1, hr = 1 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.037, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 24.8, median = 20.3 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.64, hr = 1.8 | af = 1, hr = 1 | |
| TP53- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.049, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 18.7, median = 15.3 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.48, hr = 2.6 | af = 1, hr = 1 | |
| DRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.037, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 24.8, median = 20.3 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.64, hr = 1.8 | af = 1, hr = 1 | |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.037, shape = 1.3 | scale = 0.024, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 24.8, median = 20.3 | mean = 39, median = 31.9 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.64, hr = 1.8 | af = 1, hr = 1 |
|
|
|
|
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The overall error was 0.846.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Niraparib
0.628 0.062 0.654
The overall power was .
The corresponding power separate for the different treatments were:
NULL
| signature | var | Control | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| all | graduation | 0 | 59 | 0 | 64 |
| futility | 0 | 2 | 170 | 3 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 698 (568, 775) | 365 (181, 530) | 239 (105, 356) | 331 (177, 524) | |
| n_unique | 698 (568, 775) | 365 (181, 530) | 239 (105, 356) | 331 (177, 524) | |
| time_trial | 60 (60, 60) | 60 (46, 60) | 60 (21, 60) | 60 (46, 60) | |
| time_stop | NA (NA, NA) | 36 (16, 51) | 28 (9, 52) | 31 (17, 54) | |
| post_p | NA (NA, NA) | 0.94 (0.61, 1) | 0.16 (0, 0.68) | 0.94 (0.6, 1) | |
| rate | 0.024 (0.023, 0.026) | 0.021 (0.019, 0.024) | 0.028 (0.024, 0.035) | 0.021 (0.02, 0.024) | |
| TP53- | graduation | 0 | 29 | 31 | 19 |
| futility | 0 | 163 | 151 | 181 | |
| max_n | 0 | 77 | 66 | 62 | |
| n | 390 (317, 431) | 177 (62, 302) | 186 (56, 302) | 164 (58, 300) | |
| n_unique | 390 (317, 431) | 177 (62, 302) | 186 (56, 302) | 164 (58, 300) | |
| time_trial | 60 (60, 60) | 60 (21, 60) | 60 (22, 60) | 60 (20, 60) | |
| time_stop | NA (NA, NA) | 29 (16, 50) | 28 (18, 53) | 29 (16, 48) | |
| post_p | NA (NA, NA) | 0.47 (0.08, 0.9) | 0.52 (0.1, 0.9) | 0.5 (0.07, 0.89) | |
| rate | 0.021 (0.019, 0.023) | 0.022 (0.019, 0.026) | 0.021 (0.019, 0.026) | 0.022 (0.019, 0.026) | |
| TP53+ | graduation | 0 | 277 | 0 | 285 |
| futility | 0 | 11 | 371 | 6 | |
| max_n | 0 | 32 | 0 | 22 | |
| n | 322 (200, 365) | 181 (68, 288) | 52 (37, 73) | 170 (69, 280) | |
| n_unique | 322 (200, 365) | 181 (68, 288) | 52 (37, 73) | 170 (69, 280) | |
| time_trial | 60 (60, 60) | 54 (22, 60) | 35 (19, 60) | 52 (23, 60) | |
| time_stop | NA (NA, NA) | 35 (20, 55) | 30 (18, 48) | 35 (20, 55) | |
| post_p | NA (NA, NA) | 0.99 (0.89, 1) | 0 (0, 0.01) | 0.99 (0.9, 1) | |
| rate | 0.029 (0.026, 0.032) | 0.021 (0.019, 0.024) | 0.053 (0.046, 0.063) | 0.021 (0.019, 0.024) | |
| DRD+ | graduation | 0 | 48 | 0 | 69 |
| futility | 0 | 26 | 119 | 44 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 192 (142, 224) | 86 (39, 142) | 55 (22, 98) | 105 (58, 160) | |
| n_unique | 192 (142, 224) | 86 (39, 142) | 55 (22, 98) | 105 (58, 160) | |
| time_trial | 60 (60, 60) | 60 (47, 60) | 60 (42, 60) | 60 (33, 60) | |
| time_stop | NA (NA, NA) | 42 (28, 57) | 43 (32, 56) | 34 (19, 55) | |
| post_p | NA (NA, NA) | 0.78 (0.32, 0.97) | 0.27 (0.02, 0.75) | 0.79 (0.31, 0.98) | |
| rate | 0.024 (0.021, 0.028) | 0.021 (0.017, 0.025) | 0.028 (0.022, 0.038) | 0.022 (0.019, 0.026) | |
| TEfus+ | graduation | 0 | 76 | 1 | 73 |
| futility | 0 | 30 | 209 | 24 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 252 (189, 292) | 124 (55, 199) | 70 (36, 127) | 128 (59, 203) | |
| n_unique | 252 (189, 292) | 124 (55, 199) | 70 (36, 127) | 128 (59, 203) | |
| time_trial | 60 (60, 60) | 60 (37, 60) | 60 (26, 60) | 60 (36, 60) | |
| time_stop | NA (NA, NA) | 38 (22, 58) | 34 (21, 54) | 35 (19, 55) | |
| post_p | NA (NA, NA) | 0.88 (0.41, 0.99) | 0.16 (0.01, 0.7) | 0.9 (0.44, 0.99) | |
| rate | 0.025 (0.023, 0.028) | 0.021 (0.018, 0.025) | 0.03 (0.024, 0.04) | 0.021 (0.019, 0.026) |
| subtype | var | Control | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| — | graduation | 0 | 232 | 224 | 246 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 75 | 66 | 59 | |
| n | 216 (171, 249) | 96 (32, 193) | 92 (23, 192) | 73 (19, 175) | |
| n_unique | 216 (171, 249) | 96 (32, 193) | 92 (23, 192) | 73 (19, 175) | |
| post_p | NA (NA, NA) | 0.46 (0.1, 0.88) | 0.46 (0.11, 0.88) | 0.44 (0.09, 0.88) | |
| rate | 0.021 (0.019, 0.024) | 0.022 (0.018, 0.029) | 0.022 (0.018, 0.029) | 0.022 (0.018, 0.03) | |
| –+ | graduation | 0 | 277 | 319 | 293 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 69 | 63 | 57 | |
| n | 61 (39, 77) | 22 (8, 58) | 24 (9, 62) | 22 (6, 55) | |
| n_unique | 61 (39, 77) | 22 (8, 58) | 24 (9, 62) | 22 (6, 55) | |
| post_p | NA (NA, NA) | 0.48 (0.14, 0.87) | 0.53 (0.13, 0.91) | 0.47 (0.12, 0.86) | |
| rate | 0.021 (0.017, 0.026) | 0.022 (0.016, 0.034) | 0.022 (0.015, 0.033) | 0.022 (0.015, 0.037) | |
| -+- | graduation | 0 | 300 | 455 | 310 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 32 | 0 | 22 | |
| n | 137 (87, 162) | 80 (29, 138) | 20 (12, 34) | 60 (18, 126) | |
| n_unique | 137 (87, 162) | 80 (29, 138) | 20 (12, 34) | 60 (18, 126) | |
| post_p | NA (NA, NA) | 0.94 (0.63, 1) | 0.01 (0, 0.1) | 0.93 (0.54, 1) | |
| rate | 0.029 (0.025, 0.034) | 0.021 (0.018, 0.027) | 0.054 (0.044, 0.072) | 0.021 (0.016, 0.027) | |
| -++ | graduation | 0 | 335 | 472 | 339 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 30 | 0 | 22 | |
| n | 98 (57, 119) | 53 (18, 99) | 17 (10, 29) | 44 (16, 96) | |
| n_unique | 98 (57, 119) | 53 (18, 99) | 17 (10, 29) | 44 (16, 96) | |
| post_p | NA (NA, NA) | 0.9 (0.5, 1) | 0.02 (0, 0.18) | 0.91 (0.51, 1) | |
| rate | 0.029 (0.024, 0.035) | 0.022 (0.017, 0.029) | 0.054 (0.043, 0.076) | 0.021 (0.017, 0.028) | |
| +– | graduation | 0 | 268 | 282 | 288 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 70 | 64 | 58 | |
| n | 55 (39, 70) | 21 (6, 47) | 20 (4, 46) | 26 (10, 53) | |
| n_unique | 55 (39, 70) | 21 (6, 47) | 20 (4, 46) | 26 (10, 53) | |
| post_p | NA (NA, NA) | 0.5 (0.16, 0.89) | 0.51 (0.14, 0.86) | 0.52 (0.11, 0.88) | |
| rate | 0.021 (0.016, 0.027) | 0.021 (0.014, 0.036) | 0.022 (0.014, 0.038) | 0.022 (0.016, 0.033) | |
| +-+ | graduation | 0 | 304 | 353 | 324 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 65 | 61 | 56 | |
| n | 54 (34, 68) | 20 (5, 46) | 17 (4, 45) | 23 (11, 52) | |
| n_unique | 54 (34, 68) | 20 (5, 46) | 17 (4, 45) | 23 (11, 52) | |
| post_p | NA (NA, NA) | 0.46 (0.11, 0.84) | 0.49 (0.12, 0.84) | 0.47 (0.14, 0.87) | |
| rate | 0.021 (0.017, 0.027) | 0.022 (0.015, 0.036) | 0.022 (0.014, 0.04) | 0.023 (0.016, 0.033) | |
| ++- | graduation | 0 | 324 | 462 | 345 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 32 | 0 | 21 | |
| n | 41 (25, 54) | 18 (5, 39) | 6 (2, 13) | 23 (10, 44) | |
| n_unique | 41 (25, 54) | 18 (5, 39) | 6 (2, 13) | 23 (10, 44) | |
| post_p | NA (NA, NA) | 0.79 (0.33, 0.97) | 0.15 (0.03, 0.42) | 0.84 (0.37, 0.98) | |
| rate | 0.029 (0.022, 0.038) | 0.021 (0.013, 0.036) | 0.057 (0.036, 0.103) | 0.022 (0.016, 0.032) | |
| +++ | graduation | 0 | 353 | 477 | 365 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 30 | 0 | 21 | |
| n | 40 (22, 53) | 18 (5, 38) | 6 (2, 14) | 23 (10, 44) | |
| n_unique | 40 (22, 53) | 18 (5, 38) | 6 (2, 14) | 23 (10, 44) | |
| post_p | NA (NA, NA) | 0.77 (0.34, 0.97) | 0.15 (0.03, 0.41) | 0.82 (0.38, 0.98) | |
| rate | 0.029 (0.022, 0.038) | 0.021 (0.014, 0.034) | 0.056 (0.036, 0.123) | 0.022 (0.015, 0.032) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|
| all | count | 59 | 64 | |
| time_stop | 36 (16, 51) | 32 (17, 54) | ||
| n_trt | 244 (119, 451) | 224 (113, 426) | ||
| n_control | 411 (182, 617) | 375 (176, 653) | ||
| post_p | 1 (0.96, 1) | 0.99 (0.94, 1) | ||
| order | 2 (1, 4) | 2 (1, 4) | ||
| TP53- | count | 29 | 31 | 19 |
| time_stop | 30 (16, 47) | 24 (16, 54) | 37 (18, 54) | |
| n_trt | 106 (63, 173) | 108 (67, 245) | 113 (68, 272) | |
| n_control | 181 (96, 295) | 147 (99, 335) | 273 (133, 382) | |
| post_p | 0.96 (0.89, 0.99) | 0.96 (0.89, 0.99) | 0.98 (0.95, 1) | |
| order | 2 (1, 4) | 1 (1, 4) | 3 (1, 4.2) | |
| TP53+ | count | 277 | 285 | |
| time_stop | 37 (20, 55) | 35 (20, 55) | ||
| n_trt | 132 (64, 244) | 126 (65, 227) | ||
| n_control | 195 (99, 317) | 185 (105, 297) | ||
| post_p | 0.99 (0.93, 1) | 0.99 (0.96, 1) | ||
| order | 2 (1, 3) | 1 (1, 3) | ||
| DRD+ | count | 48 | 69 | |
| time_stop | 44 (28, 57) | 41 (20, 57) | ||
| n_trt | 72 (53, 123) | 95 (56, 146) | ||
| n_control | 139 (93, 183) | 125 (64, 186) | ||
| post_p | 0.98 (0.94, 1) | 0.98 (0.94, 1) | ||
| order | 2.5 (2, 4.3) | 3 (1, 4) | ||
| TEfus+ | count | 76 | 1 | 73 |
| time_stop | 40 (22, 59) | 22 (22, 22) | 36 (19, 56) | |
| n_trt | 92 (55, 188) | 57 (57, 57) | 88 (57, 166) | |
| n_control | 172 (94, 260) | 79 (79, 79) | 159 (74, 243) | |
| post_p | 0.98 (0.94, 1) | 0.99 (0.99, 0.99) | 0.98 (0.93, 1) | |
| order | 3 (1, 5) | 2 (2, 2) | 2 (1, 5) |
| signature | var | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|
| all | count | 2 | 170 | 3 |
| time_stop | 32 (29, 35) | 28 (9, 52) | 20 (12, 22) | |
| n_trt | 189 (147, 231) | 133 (63, 237) | 100 (65, 117) | |
| n_control | 368 (338, 398) | 325 (94, 605) | 241 (131, 273) | |
| post_p | 0.11 (0.06, 0.16) | 0.02 (0, 0.12) | 0.08 (0.04, 0.14) | |
| order | 4.5 (4.1, 4.9) | 2 (1, 4.1) | 2 (1.2, 2) | |
| TP53- | count | 163 | 151 | 181 |
| time_stop | 29 (16, 50) | 28 (18, 53) | 29 (16, 47) | |
| n_trt | 89 (52, 189) | 94 (57, 194) | 83 (51, 204) | |
| n_control | 182 (95, 337) | 175 (104, 341) | 182 (90, 317) | |
| post_p | 0.14 (0.05, 0.26) | 0.15 (0.05, 0.26) | 0.13 (0.04, 0.24) | |
| order | 2 (1, 4) | 3 (1, 5) | 2 (1, 4) | |
| TP53+ | count | 11 | 371 | 6 |
| time_stop | 23 (17, 34) | 30 (18, 48) | 26 (19, 48) | |
| n_trt | 70 (55, 81) | 54 (50, 75) | 70 (51, 108) | |
| n_control | 116 (92, 194) | 158 (87, 276) | 139 (94, 263) | |
| post_p | 0.2 (0.1, 0.26) | 0.01 (0, 0.14) | 0.11 (0.05, 0.26) | |
| order | 1 (1, 3) | 1 (1, 3) | 1.5 (1, 4) | |
| DRD+ | count | 26 | 119 | 44 |
| time_stop | 40 (29, 56) | 43 (32, 56) | 28 (19, 48) | |
| n_trt | 61 (50, 114) | 58 (50, 89) | 63 (54, 100) | |
| n_control | 126 (91, 185) | 143 (101, 188) | 92 (54, 147) | |
| post_p | 0.15 (0.07, 0.28) | 0.13 (0.02, 0.27) | 0.14 (0.05, 0.26) | |
| order | 3 (2, 6) | 3 (2, 5) | 3 (1, 4.7) | |
| TEfus+ | count | 30 | 209 | 24 |
| time_stop | 33 (23, 48) | 34 (21, 54) | 32 (19, 48) | |
| n_trt | 68 (50, 116) | 61 (50, 96) | 58 (50, 128) | |
| n_control | 142 (91, 193) | 142 (86, 226) | 138 (73, 216) | |
| post_p | 0.13 (0.04, 0.29) | 0.08 (0.01, 0.24) | 0.14 (0.05, 0.26) | |
| order | 3 (1, 4.1) | 3 (1, 5) | 2 (1, 5) |
| signature | treatment | var | — | –+ | -+- | -++ | +– | +-+ | ++- | +++ |
|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 59 | 59 | 59 | 59 | 59 | 59 | 59 | 59 |
| time | 36 (16, 51) | 36 (16, 51) | 36 (16, 51) | 36 (16, 51) | 36 (16, 51) | 36 (16, 51) | 36 (16, 51) | 36 (16, 51) | ||
| n | 83 (36, 165) | 20 (9, 42) | 49 (20, 88) | 27 (11, 62) | 17 (7, 35) | 13 (6, 32) | 8 (4, 26) | 11 (2, 28) | ||
| post_p | 0.7 (0.57, 0.91) | 0.66 (0.56, 0.86) | 0.94 (0.61, 0.99) | 0.8 (0.63, 0.98) | 0.63 (0.56, 0.84) | 0.63 (0.56, 0.86) | 0.7 (0.57, 0.86) | 0.74 (0.56, 0.93) | ||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.017 (0.012, 0.021) | 0.013 (0, 0.022) | 0.016 (0.009, 0.022) | 0.017 (0.004, 0.024) | 0.012 (0, 0.019) | 0.012 (0, 0.019) | 0.015 (0, 0.023) | 0.012 (0, 0.024) | ||
| Niraparib | count | 64 | 64 | 64 | 64 | 64 | 64 | 64 | 64 | |
| time | 32 (17, 54) | 32 (17, 54) | 32 (17, 54) | 32 (17, 54) | 32 (17, 54) | 32 (17, 54) | 32 (17, 54) | 32 (17, 54) | ||
| n | 56 (14, 139) | 14 (6, 46) | 36 (13, 96) | 28 (10, 68) | 18 (10, 39) | 20 (9, 38) | 17 (8, 29) | 16 (8, 32) | ||
| post_p | 0.7 (0.59, 0.89) | 0.63 (0.56, 0.78) | 0.87 (0.63, 0.99) | 0.79 (0.59, 0.98) | 0.69 (0.57, 0.89) | 0.67 (0.56, 0.86) | 0.77 (0.59, 0.96) | 0.8 (0.6, 0.96) | ||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||
| rate | 0.015 (0, 0.019) | 0.013 (0, 0.022) | 0.017 (0, 0.023) | 0.018 (0.005, 0.025) | 0.015 (0.006, 0.023) | 0.016 (0.003, 0.021) | 0.017 (0.007, 0.025) | 0.015 (0, 0.024) | ||
| TP53- | Hormone_therapies | count | 29 | 29 | 29 | 29 | ||||
| time | 30 (16, 47) | 30 (16, 47) | 30 (16, 47) | 30 (16, 47) | ||||||
| n | 64 (39, 104) | 16 (9, 32) | 10 (4, 25) | 9 (4, 22) | ||||||
| post_p | 0.81 (0.74, 0.92) | 0.74 (0.63, 0.86) | 0.72 (0.61, 0.85) | 0.72 (0.61, 0.84) | ||||||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.014 (0.008, 0.019) | 0.011 (0, 0.018) | 0.006 (0, 0.016) | 0.009 (0, 0.016) | ||||||
| Taxel_therapies | count | 31 | 31 | 31 | 31 | |||||
| time | 24 (16, 54) | 24 (16, 54) | 24 (16, 54) | 24 (16, 54) | ||||||
| n | 57 (36, 119) | 19 (10, 39) | 14 (6, 33) | 13 (4, 45) | ||||||
| post_p | 0.77 (0.71, 0.96) | 0.74 (0.7, 0.91) | 0.73 (0.6, 0.86) | 0.76 (0.63, 0.88) | ||||||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.015 (0.007, 0.02) | 0.014 (0.005, 0.019) | 0.005 (0, 0.019) | 0.006 (0, 0.016) | ||||||
| Niraparib | count | 19 | 19 | 19 | 19 | |||||
| time | 37 (18, 54) | 37 (18, 54) | 37 (18, 54) | 37 (18, 54) | ||||||
| n | 56 (27, 146) | 17 (9, 47) | 20 (14, 47) | 28 (13, 45) | ||||||
| post_p | 0.8 (0.73, 0.94) | 0.78 (0.66, 0.89) | 0.81 (0.7, 0.93) | 0.74 (0.7, 0.92) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.016 (0.004, 0.019) | 0.011 (0, 0.018) | 0.012 (0.003, 0.019) | 0.012 (0, 0.02) | ||||||
| TP53+ | Hormone_therapies | count | 277 | 277 | 277 | 277 | ||||
| time | 37 (20, 55) | 37 (20, 55) | 37 (20, 55) | 37 (20, 55) | ||||||
| n | 61 (27, 112) | 43 (20, 85) | 15 (4, 32) | 15 (5, 31) | ||||||
| post_p | 0.89 (0.72, 0.99) | 0.85 (0.71, 0.99) | 0.75 (0.62, 0.94) | 0.74 (0.62, 0.93) | ||||||
| r_prob | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.018 (0.01, 0.024) | 0.017 (0.008, 0.023) | 0.013 (0, 0.022) | 0.013 (0, 0.022) | ||||||
| Niraparib | count | 285 | 285 | 285 | 285 | |||||
| time | 35 (20, 55) | 35 (20, 55) | 35 (20, 55) | 35 (20, 55) | ||||||
| n | 48 (18, 102) | 34 (16, 73) | 20 (9, 38) | 19 (10, 37) | ||||||
| post_p | 0.85 (0.72, 0.98) | 0.82 (0.71, 0.98) | 0.8 (0.7, 0.96) | 0.79 (0.7, 0.95) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.016 (0.008, 0.023) | 0.017 (0.009, 0.023) | 0.017 (0.007, 0.025) | 0.017 (0.008, 0.024) | ||||||
| DRD+ | Hormone_therapies | count | 48 | 48 | 48 | 48 | ||||
| time | 44 (28, 57) | 44 (28, 57) | 44 (28, 57) | 44 (28, 57) | ||||||
| n | 24 (9, 40) | 20 (8, 40) | 16 (5, 32) | 16 (6, 36) | ||||||
| post_p | 0.79 (0.69, 0.92) | 0.73 (0.63, 0.89) | 0.83 (0.72, 0.95) | 0.81 (0.67, 0.97) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.012 (0.006, 0.017) | 0.015 (0.006, 0.02) | 0.014 (0.003, 0.022) | 0.014 (0.006, 0.024) | ||||||
| Niraparib | count | 69 | 69 | 69 | 69 | |||||
| time | 41 (20, 57) | 41 (20, 57) | 41 (20, 57) | 41 (20, 57) | ||||||
| n | 24 (12, 47) | 24 (13, 47) | 21 (9, 37) | 20 (8, 38) | ||||||
| post_p | 0.75 (0.7, 0.9) | 0.78 (0.71, 0.95) | 0.81 (0.71, 0.96) | 0.84 (0.71, 0.97) | ||||||
| r_prob | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.016 (0.005, 0.023) | 0.015 (0.004, 0.02) | 0.018 (0.006, 0.025) | 0.017 (0.007, 0.024) | ||||||
| TEfus+ | Hormone_therapies | count | 76 | 76 | 76 | 76 | ||||
| time | 40 (22, 59) | 40 (22, 59) | 40 (22, 59) | 40 (22, 59) | ||||||
| n | 23 (10, 50) | 38 (18, 85) | 17 (7, 38) | 14 (5, 33) | ||||||
| post_p | 0.76 (0.68, 0.92) | 0.9 (0.73, 0.99) | 0.74 (0.62, 0.88) | 0.78 (0.63, 0.94) | ||||||
| r_prob | 0.19 (0.19, 0.19) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.014 (0.006, 0.018) | 0.017 (0.008, 0.024) | 0.012 (0, 0.019) | 0.015 (0, 0.024) | ||||||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | |||||
| time | 22 (22, 22) | 22 (22, 22) | 22 (22, 22) | 22 (22, 22) | ||||||
| n | 11 (11, 11) | 27 (27, 27) | 9 (9, 9) | 10 (10, 10) | ||||||
| post_p | 0.78 (0.78, 0.78) | 0.98 (0.98, 0.98) | 0.69 (0.69, 0.69) | 0.61 (0.61, 0.61) | ||||||
| r_prob | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0 (0, 0) | 0.009 (0.009, 0.009) | 0 (0, 0) | 0.016 (0.016, 0.016) | ||||||
| Niraparib | count | 73 | 73 | 73 | 73 | |||||
| time | 36 (19, 56) | 36 (19, 56) | 36 (19, 56) | 36 (19, 56) | ||||||
| n | 19 (7, 45) | 28 (13, 68) | 22 (12, 41) | 18 (9, 33) | ||||||
| post_p | 0.75 (0.63, 0.92) | 0.85 (0.71, 0.99) | 0.74 (0.7, 0.86) | 0.82 (0.71, 0.96) | ||||||
| r_prob | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.012 (0, 0.019) | 0.016 (0.006, 0.024) | 0.013 (0.004, 0.021) | 0.016 (0.007, 0.023) |
| signature | treatment | var | — | –+ | -+- | -++ | +– | +-+ | ++- | +++ |
|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| time | 32 (29, 35) | 32 (29, 35) | 32 (29, 35) | 32 (29, 35) | 32 (29, 35) | 32 (29, 35) | 32 (29, 35) | 32 (29, 35) | ||
| n | 62 (36, 88) | 21 (21, 21) | 47 (45, 49) | 8 (7, 8) | 24 (12, 35) | 5 (3, 7) | 10 (9, 12) | 12 (9, 16) | ||
| post_p | 0.4 (0.34, 0.47) | 0.24 (0.23, 0.25) | 0.49 (0.48, 0.5) | 0.3 (0.21, 0.4) | 0.33 (0.2, 0.45) | 0.27 (0.21, 0.33) | 0.32 (0.24, 0.4) | 0.32 (0.24, 0.39) | ||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.019 (0.019, 0.02) | 0.027 (0.024, 0.029) | 0.026 (0.021, 0.031) | 0.035 (0.031, 0.039) | 0.026 (0.019, 0.034) | 0.043 (0.034, 0.052) | 0.027 (0.019, 0.036) | 0.036 (0.025, 0.046) | ||
| Taxel_therapies | count | 170 | 170 | 170 | 170 | 170 | 170 | 170 | 170 | |
| time | 28 (9, 52) | 28 (9, 52) | 28 (9, 52) | 28 (9, 52) | 28 (9, 52) | 28 (9, 52) | 28 (9, 52) | 28 (9, 52) | ||
| n | 42 (15, 106) | 16 (6, 35) | 18 (12, 33) | 14 (9, 26) | 8 (2, 23) | 9 (2, 25) | 5 (1, 12) | 5 (1, 10) | ||
| post_p | 0.35 (0.13, 0.48) | 0.36 (0.16, 0.48) | 0.09 (0, 0.36) | 0.1 (0.01, 0.36) | 0.39 (0.2, 0.48) | 0.37 (0.18, 0.48) | 0.25 (0.07, 0.46) | 0.26 (0.05, 0.45) | ||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.022 (0.015, 0.031) | 0.023 (0.015, 0.047) | 0.048 (0.031, 0.071) | 0.048 (0.032, 0.082) | 0.023 (0, 0.046) | 0.024 (0, 0.057) | 0.051 (0.022, 0.103) | 0.05 (0.022, 0.136) | ||
| Niraparib | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
| time | 20 (12, 22) | 20 (12, 22) | 20 (12, 22) | 20 (12, 22) | 20 (12, 22) | 20 (12, 22) | 20 (12, 22) | 20 (12, 22) | ||
| n | 19 (9, 29) | 3 (3, 9) | 12 (9, 19) | 16 (5, 18) | 8 (7, 10) | 12 (12, 15) | 6 (6, 9) | 11 (11, 17) | ||
| post_p | 0.34 (0.25, 0.39) | 0.39 (0.23, 0.4) | 0.3 (0.24, 0.39) | 0.35 (0.33, 0.35) | 0.42 (0.39, 0.47) | 0.35 (0.22, 0.37) | 0.46 (0.45, 0.47) | 0.44 (0.41, 0.47) | ||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||
| rate | 0.018 (0.015, 0.049) | 0.03 (0.006, 0.032) | 0.036 (0.033, 0.042) | 0.027 (0.023, 0.085) | 0.021 (0.016, 0.023) | 0.016 (0.015, 0.027) | 0.032 (0.006, 0.032) | 0.019 (0.018, 0.027) | ||
| TP53- | Hormone_therapies | count | 163 | 163 | 163 | 163 | ||||
| time | 29 (16, 50) | 29 (16, 50) | 29 (16, 50) | 29 (16, 50) | ||||||
| n | 48 (26, 116) | 14 (5, 35) | 11 (4, 32) | 10 (4, 30) | ||||||
| post_p | 0.3 (0.09, 0.47) | 0.35 (0.15, 0.48) | 0.36 (0.19, 0.48) | 0.37 (0.2, 0.48) | ||||||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.021 (0.016, 0.029) | 0.024 (0.015, 0.043) | 0.024 (0.014, 0.053) | 0.024 (0.013, 0.054) | ||||||
| Taxel_therapies | count | 151 | 151 | 151 | 151 | |||||
| time | 28 (18, 53) | 28 (18, 53) | 28 (18, 53) | 28 (18, 53) | ||||||
| n | 51 (23, 121) | 17 (7, 37) | 11 (4, 26) | 11 (4, 27) | ||||||
| post_p | 0.33 (0.13, 0.48) | 0.37 (0.17, 0.48) | 0.36 (0.2, 0.47) | 0.36 (0.15, 0.47) | ||||||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.021 (0.017, 0.028) | 0.023 (0.015, 0.039) | 0.026 (0.015, 0.047) | 0.025 (0.016, 0.055) | ||||||
| Niraparib | count | 181 | 181 | 181 | 181 | |||||
| time | 29 (16, 47) | 29 (16, 47) | 29 (16, 47) | 29 (16, 47) | ||||||
| n | 36 (16, 116) | 12 (5, 36) | 15 (8, 36) | 17 (9, 34) | ||||||
| post_p | 0.34 (0.1, 0.47) | 0.35 (0.16, 0.47) | 0.35 (0.12, 0.48) | 0.36 (0.14, 0.48) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.021 (0.015, 0.033) | 0.024 (0.016, 0.046) | 0.024 (0.015, 0.037) | 0.024 (0.017, 0.036) | ||||||
| TP53+ | Hormone_therapies | count | 11 | 11 | 11 | 11 | ||||
| time | 23 (17, 34) | 23 (17, 34) | 23 (17, 34) | 23 (17, 34) | ||||||
| n | 38 (25, 50) | 12 (8, 29) | 11 (4, 15) | 5 (2, 10) | ||||||
| post_p | 0.4 (0.14, 0.48) | 0.42 (0.2, 0.49) | 0.37 (0.19, 0.48) | 0.42 (0.33, 0.46) | ||||||
| r_prob | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.023 (0.018, 0.034) | 0.029 (0.019, 0.042) | 0.026 (0.017, 0.062) | 0.036 (0.015, 0.052) | ||||||
| Taxel_therapies | count | 371 | 371 | 371 | 371 | |||||
| time | 30 (18, 48) | 30 (18, 48) | 30 (18, 48) | 30 (18, 48) | ||||||
| n | 23 (13, 37) | 18 (11, 30) | 7 (3, 13) | 7 (3, 15) | ||||||
| post_p | 0.07 (0, 0.38) | 0.11 (0.01, 0.42) | 0.31 (0.08, 0.47) | 0.29 (0.06, 0.46) | ||||||
| r_prob | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.048 (0.032, 0.071) | 0.045 (0.03, 0.073) | 0.047 (0.023, 0.101) | 0.047 (0.024, 0.114) | ||||||
| Niraparib | count | 6 | 6 | 6 | 6 | |||||
| time | 26 (19, 48) | 26 (19, 48) | 26 (19, 48) | 26 (19, 48) | ||||||
| n | 14 (6, 44) | 22 (11, 48) | 17 (10, 19) | 11 (7, 22) | ||||||
| post_p | 0.11 (0.07, 0.4) | 0.34 (0.23, 0.47) | 0.32 (0.09, 0.45) | 0.42 (0.2, 0.46) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.046 (0.029, 0.091) | 0.027 (0.022, 0.037) | 0.029 (0.026, 0.054) | 0.037 (0.024, 0.056) | ||||||
| DRD+ | Hormone_therapies | count | 26 | 26 | 26 | 26 | ||||
| time | 40 (29, 56) | 40 (29, 56) | 40 (29, 56) | 40 (29, 56) | ||||||
| n | 21 (8, 38) | 18 (7, 39) | 13 (5, 29) | 14 (5, 24) | ||||||
| post_p | 0.4 (0.15, 0.47) | 0.3 (0.11, 0.44) | 0.39 (0.18, 0.48) | 0.37 (0.18, 0.48) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.022 (0.015, 0.041) | 0.027 (0.017, 0.036) | 0.033 (0.02, 0.043) | 0.031 (0.022, 0.054) | ||||||
| Taxel_therapies | count | 119 | 119 | 119 | 119 | |||||
| time | 43 (32, 56) | 43 (32, 56) | 43 (32, 56) | 43 (32, 56) | ||||||
| n | 23 (12, 43) | 22 (9, 38) | 7 (3, 14) | 7 (3, 15) | ||||||
| post_p | 0.37 (0.13, 0.48) | 0.39 (0.16, 0.48) | 0.21 (0.04, 0.4) | 0.21 (0.03, 0.4) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.022 (0.015, 0.035) | 0.022 (0.016, 0.031) | 0.052 (0.03, 0.1) | 0.048 (0.034, 0.121) | ||||||
| Niraparib | count | 44 | 44 | 44 | 44 | |||||
| time | 28 (19, 48) | 28 (19, 48) | 28 (19, 48) | 28 (19, 48) | ||||||
| n | 16 (9, 36) | 16 (12, 31) | 15 (10, 26) | 15 (9, 24) | ||||||
| post_p | 0.35 (0.05, 0.47) | 0.33 (0.17, 0.46) | 0.41 (0.29, 0.48) | 0.41 (0.21, 0.5) | ||||||
| r_prob | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.024 (0.015, 0.038) | 0.023 (0.017, 0.033) | 0.027 (0.018, 0.035) | 0.025 (0.016, 0.045) | ||||||
| TEfus+ | Hormone_therapies | count | 30 | 30 | 30 | 30 | ||||
| time | 33 (23, 48) | 33 (23, 48) | 33 (23, 48) | 33 (23, 48) | ||||||
| n | 16 (5, 35) | 32 (17, 55) | 10 (4, 25) | 10 (6, 20) | ||||||
| post_p | 0.35 (0.12, 0.48) | 0.39 (0.17, 0.46) | 0.32 (0.13, 0.46) | 0.43 (0.22, 0.48) | ||||||
| r_prob | 0.19 (0.19, 0.19) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.024 (0.018, 0.044) | 0.027 (0.021, 0.033) | 0.025 (0.016, 0.044) | 0.034 (0.015, 0.054) | ||||||
| Taxel_therapies | count | 209 | 209 | 209 | 209 | |||||
| time | 34 (21, 54) | 34 (21, 54) | 34 (21, 54) | 34 (21, 54) | ||||||
| n | 21 (11, 40) | 18 (11, 29) | 16 (5, 31) | 7 (3, 14) | ||||||
| post_p | 0.4 (0.16, 0.48) | 0.08 (0, 0.37) | 0.4 (0.16, 0.48) | 0.25 (0.06, 0.44) | ||||||
| r_prob | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.022 (0.015, 0.033) | 0.049 (0.033, 0.074) | 0.023 (0.014, 0.039) | 0.047 (0.029, 0.124) | ||||||
| Niraparib | count | 24 | 24 | 24 | 24 | |||||
| time | 32 (19, 48) | 32 (19, 48) | 32 (19, 48) | 32 (19, 48) | ||||||
| n | 12 (4, 24) | 23 (9, 53) | 15 (10, 30) | 18 (8, 32) | ||||||
| post_p | 0.26 (0.11, 0.43) | 0.43 (0.34, 0.48) | 0.32 (0.13, 0.44) | 0.43 (0.24, 0.48) | ||||||
| r_prob | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.032 (0.02, 0.048) | 0.028 (0.02, 0.038) | 0.027 (0.019, 0.035) | 0.03 (0.019, 0.043) |